Abstract | BACKGROUND: METHODS: RESULTS:
Laser photocoagulation increased the expression of TGF-beta 1. Expression of angiogenic factors bFGF, VEGF, IL-8 and their transcription factor, ETS1, was also increased. However, the up-regulation of these factors was observed early (6 h) after photocoagulation. Seventy-two hours after photocoagulation, when RPE cells were repaired, the expression of VEGF, IL-8, ETS-1, and NF-kappa B was decreased to the levels before photocoagulation. CONCLUSIONS: These results suggest that TGF-beta produced by photocoagulated RPE cells and the down-regulation of angiogenic factors in repaired RPE cells, in all likelihood, play an important role in the processes that occur after laser photocoagulation.
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Authors | N Ogata, A Ando, M Uyama, M Matsumura |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 239
Issue 2
Pg. 87-95
(Feb 2001)
ISSN: 0721-832X [Print] Germany |
PMID | 11372550
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- DNA Primers
- Receptors, Cytokine
- Transcription Factors
- RNA
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Topics |
- Cells, Cultured
- Cytokines
(biosynthesis, genetics)
- DNA Primers
(chemistry)
- Gene Expression
- Humans
- Laser Coagulation
- Pigment Epithelium of Eye
(cytology, metabolism, surgery)
- RNA
(biosynthesis)
- Receptors, Cytokine
(biosynthesis, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors
(biosynthesis, genetics)
- Up-Regulation
- Wound Healing
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