Clinical characteristics of ischaemic renal disease.

Abstract

BACKGROUND:

Longer life expectancy has favoured the ever more frequent development of ischaemic nephropathy characterized by the presence of atherosclerotic stenosis in both renal arteries.

METHODS:

This is an observational and multicentre study carried out during a 14-month follow-up period in 20 hospitals in SPAIN: Inclusion criteria were the presence of bilateral renal artery stenosis > 50% and a creatinine level of > or = 1.5 mg/dl. The diagnosis should be made by arterial digital angiography in every case.

RESULTS:

A total of 156 patients were included. Their mean age was 68.7+/-9 years, and 78.5% were male. The mean creatinine value of the group was 2.9+/-1.7 mg/dl. Arterial hypertension (BP) with a duration of 12+/-9 years was present in 97.4% of the cases, smoking habits in 69.8%, hypercholesterolaemia (> or = 240 mg/dl) in 62.9% and diabetes in 32.1%. Only 8% of the patients had a body mass index > or = 30 kg/m(2). Associated cardiovascular disease was very frequent: peripheral arteriopathy in 67.5% of the cases, ischaemic cardiopathy in 44.8%, cardiac insufficiency in 32.6% and stroke in 27.3%. In 94.4% of the patients, the lesion affected both renal arteries, with complete obstruction in 23% of the cases.

CONCLUSIONS:

Diagnostic suspicion of ischaemic nephropathy can be established in non-obese elderly males with chronic renal insufficiency, long-term BP evolution and cardiovascular disease at other levels, above all, peripheral arteriopathy.

• Authors: J M Alcázar, R Marín, F Gómez-Campderá, L Orte, A Rodríguez-Jornet, J Mora-Macía, Spanish Group of Ischaemic Nephrology (GEDENI)
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 16 Suppl 1 Pg. 74-7 ( 2001) ISSN: 0931-0509 [Print] England
• PMID: 11369827 (Publication Type: Journal Article)

Chemical References

• Creatinine

Topics

• Aged
• Body Mass Index
• Cardiovascular Diseases (epidemiology)
• Coronary Disease (epidemiology)
• Creatinine (metabolism)
• Female
• Heart Failure (epidemiology)
• Humans
• Hypertension (epidemiology)
• Ischemia (physiopathology)
• Kidney (blood supply)
• Male
• Myocardial Ischemia (epidemiology)
• Renal Artery Obstruction (physiopathology)
• Renal Circulation
• Risk Factors
• Smoking
• Stroke (epidemiology)