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Therapeutic effect of anti-Fas antibody on a collagen induced arthritis model.

AbstractOBJECTIVE: METHODS:
CD1F1 mice were immunized with bovine type II collagen to induce CIA and were treated with RK-8 intravenously. The effect of RK-8 was monitored by visual scoring. ELISA to detect serum anti-type II collagen antibody was performed on Day 47 and 70. Histopathological analysis was performed on Days 31 and 72. Digital micrography was performed on Day 72.
RESULTS:
RK-8 treatment almost completely prevented CIA. This suppressive effect continued after RK-8 was discontinued. RK-8 significantly suppressed the serum anti-type II collagen antibody level on Day 47. Histological analysis revealed that RK-8 significantly reduced joint histopathology, as determined by the infiltration of inflammatory cells and cartilage damage, consistent with digital micrography.
CONCLUSION:
Administration of anti-Fas Mab may be a useful therapeutic strategy for rheumatoid arthritis if used early in the disease.
AuthorsY Ogawa, H Kuwahara, T Kimura, Y Tani, S Yonehara, A Shiraishi, M Ohtsuki
JournalThe Journal of rheumatology (J Rheumatol) Vol. 28 Issue 5 Pg. 950-5 (May 2001) ISSN: 0315-162X [Print] Canada
PMID11361221 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • fas Receptor
  • Collagen
Topics
  • Animals
  • Antibodies, Monoclonal (pharmacology)
  • Antibody Formation (immunology)
  • Apoptosis (immunology)
  • Arthritis (chemically induced, immunology, therapy)
  • Collagen
  • Disease Models, Animal
  • Female
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred DBA
  • Species Specificity
  • Synovial Membrane (pathology)
  • Synovitis (chemically induced, immunology, therapy)
  • Thymus Gland (immunology, pathology)
  • fas Receptor (immunology)

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