Abstract | OBJECTIVE: METHODS: CD1F1 mice were immunized with bovine type II collagen to induce CIA and were treated with RK-8 intravenously. The effect of RK-8 was monitored by visual scoring. ELISA to detect serum anti- type II collagen antibody was performed on Day 47 and 70. Histopathological analysis was performed on Days 31 and 72. Digital micrography was performed on Day 72. RESULTS: RK-8 treatment almost completely prevented CIA. This suppressive effect continued after RK-8 was discontinued. RK-8 significantly suppressed the serum anti- type II collagen antibody level on Day 47. Histological analysis revealed that RK-8 significantly reduced joint histopathology, as determined by the infiltration of inflammatory cells and cartilage damage, consistent with digital micrography. CONCLUSION: Administration of anti-Fas Mab may be a useful therapeutic strategy for rheumatoid arthritis if used early in the disease.
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Authors | Y Ogawa, H Kuwahara, T Kimura, Y Tani, S Yonehara, A Shiraishi, M Ohtsuki |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 28
Issue 5
Pg. 950-5
(May 2001)
ISSN: 0315-162X [Print] Canada |
PMID | 11361221
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- fas Receptor
- Collagen
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Topics |
- Animals
- Antibodies, Monoclonal
(pharmacology)
- Antibody Formation
(immunology)
- Apoptosis
(immunology)
- Arthritis
(chemically induced, immunology, therapy)
- Collagen
- Disease Models, Animal
- Female
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Inbred DBA
- Species Specificity
- Synovial Membrane
(pathology)
- Synovitis
(chemically induced, immunology, therapy)
- Thymus Gland
(immunology, pathology)
- fas Receptor
(immunology)
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