Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils.

Abstract

BACKGROUND AND AIMS:

Body gastritis caused by Helicobacter pylori infection appears to inhibit gastric acid secretion. The aim of this study was to determine the effects of H pylori infection on gastric acid secretion and clarify its mechanisms with reference to interleukin 1beta (IL-1beta).

METHODS:

(1) Mongolian gerbils were inoculated orally with H pylori. Before, six, and 12 weeks after inoculation, serum gastrin levels, gastric acid output, and IL-1beta mRNA levels in the gastric mucosa were determined. Pathological changes were also determined according to the updated Sydney system. (2) Effects of recombinant human IL-1 receptor antagonist (rhIL-1ra) on gastric acid output and serum gastrin levels were also determined.

RESULTS:

(1) Scores for activity and inflammation of gastritis and serum gastrin levels were significantly increased, and gastric acid output was significantly decreased six and 12 weeks after inoculation with H pylori. IL-1beta mRNA levels in the gastric mucosa were also elevated six and 12 weeks after inoculation with H pylori. (2) Acid output and serum gastrin levels in the infected groups returned to control levels after rhIL-1ra injection.

CONCLUSIONS:

Gastric acid secretion is decreased and serum gastrin levels are increased in Mongolian gerbils infected with H pylori. This change in gastric acid secretion appears to be mediated by IL-1beta induced by H pylori infection.

• Authors: M Takashima, T Furuta, H Hanai, H Sugimura, E Kaneko
• Journal: Gut (Gut) Vol. 48 Issue 6 Pg. 765-73 (Jun 2001) ISSN: 0017-5749 [Print] England
• PMID: 11358893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gastrins
• Interleukin-1
• RNA, Messenger
• Receptors, Interleukin-1

Topics

• Analysis of Variance
• Animals
• Electrophoresis, Agar Gel
• Gastric Acid (metabolism)
• Gastric Mucosa (metabolism)
• Gastrins (analysis, metabolism)
• Gastritis (metabolism, microbiology)
• Gerbillinae
• Helicobacter Infections (complications, metabolism, pathology)
• Helicobacter pylori
• Interleukin-1 (analysis, genetics, metabolism)
• Male
• Neutrophil Infiltration
• RNA, Messenger (analysis)
• Receptors, Interleukin-1 (antagonists & inhibitors, metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Sequence Analysis, DNA
• Specific Pathogen-Free Organisms
• Statistics, Nonparametric