Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men.

Abstract

Men with higher endogenous 5alpha-reductase activity may have higher prostate cancer risk. This hypothesis raises two questions: (a) Could racial differences in 5alpha-reductase activity explain the observed racial differences in prostate cancer risk? and (b) Could a man reduce his activity level by modifying his lifestyle? To address these questions, we measured two hormonal indices of 5alpha-reductase activity [serum levels of androstane-3alpha-17beta-diol glucuronide (3alpha-diol G) and androsterone glucuronide (AG)] in healthy, older African-American, white, and Asian-American men, who are at high, intermediate, and low prostate cancer risk, respectively. We also examined associations between these metabolite levels and such lifestyle characteristics as body size and physical activity as well as select aspects of medical history and family history of prostate cancer. Men included in this cross-sectional analysis (n = 1054) had served as control subjects in a population-based case-control study of prostate cancer we conducted in California, Hawaii, and Vancouver, Canada and provided information on certain personal attributes and donated blood between March 1990 and March 1992. In this study, concentrations of 3alpha-diol G declined significantly with age and increased significantly with body mass index. Mean levels of 3alpha-diol G, adjusted for age and body mass index, were 6.1 ng/ml in African-Americans, 6.9 ng/ml in whites and 4.8 ng/ml in Asian-Americans. These differences were statistically significant (African-Americans versus whites: P < 0.01; whites versus Asian-Americans: P < 0.001). Concentrations of AG decreased significantly with age, but only in whites, and were unrelated to any of the reported personal attributes. Mean levels of AG, adjusted for age, were 44.1 ng/ml in African-Americans, 44.9 ng/ml in whites, and 37.5 ng/ml in Asian-Americans (Asian-Americans versus whites, P < 0.001). In conclusion, older African-American and white men have similar levels of these two indices of 5alpha-reductase activity, and these levels are higher than those of older Asian-American men. This difference may be related to the lower prostate cancer risk in Asian-Americans.

• Authors: A H Wu, A S Whittemore, L N Kolonel, F Z Stanczyk, E M John, R P Gallagher, D W West
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 10 Issue 5 Pg. 533-8 (May 2001) ISSN: 1055-9965 [Print] United States
• PMID: 11352865 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers
• androsterone glucuronide
• Androstane-3,17-diol
• androstane-3,17-diol glucuronide
• Androsterone
• Oxidoreductases
• Cholestenone 5 alpha-Reductase

Topics

• Age Distribution
• Aged
• Aged, 80 and over
• Aging (metabolism)
• Analysis of Variance
• Androstane-3,17-diol (analogs & derivatives, metabolism)
• Androsterone (analogs & derivatives, metabolism)
• Asian People
• Biomarkers (analysis)
• Black People
• British Columbia (epidemiology)
• California (epidemiology)
• Case-Control Studies
• Cholestenone 5 alpha-Reductase
• Hawaii (epidemiology)
• Humans
• Life Style
• Male
• Middle Aged
• Oxidoreductases (analysis, metabolism)
• Population Surveillance
• Prostatic Neoplasms (enzymology, ethnology)
• Reference Values
• Risk Assessment
• Risk Factors
• Sensitivity and Specificity
• White People