Abstract | BACKGROUND: OBJECTIVE: DESIGN: Six case-control studies from the Copenhagen City Heart Study. SETTING: Copenhagen, Denmark. PARTICIPANTS: MEASUREMENTS: RESULTS: Relative allele frequencies of 235T and 174M in the general population were 0.41 and 0.12, respectively. Genotype was not associated with increased risk for ischemic heart or ischemic cerebrovascular disease in studies of either mutation alone or combined in women or men. Among compound heterozygotes (235MT /174TM ), women in case-control study 2a had decreased risk for ischemic heart disease in age-adjusted analysis; however, this decreased risk was not seen in multifactorial-adjusted or matched analyses, in men, or in case-control study 1a. Among double homozygotes (235TT /174MM ), women in case-control study 2b had increased risk for myocardial infarction in matched analysis; however, this increased risk was not seen in age- or multifactorial-adjusted analyses, in men, or in case-control study 1b. Among single homozygotes (235TT /174TT ), men in case-control study 2b had increased risk for myocardial infarction in multifactorial-adjusted and matched analyses. This risk was not present in age-adjusted analysis, in women, or in case-control study 1b. In addition, male single homozygotes had decreased risk for ischemic cerebrovascular disease in case-control study 2c in age- and multifactorial-adjusted analyses, but this finding was not seen in matched analysis, in women, or in case-control study 1c. CONCLUSIONS:
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Authors | A A Sethi, A Tybjaerg-Hansen, M L Grønholdt, R Steffensen, P Schnohr, B G Nordestgaard |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 134
Issue 10
Pg. 941-54
(May 15 2001)
ISSN: 0003-4819 [Print] United States |
PMID | 11352695
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Angiotensinogen
(genetics)
- Brain Ischemia
(genetics)
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Heterozygote
- Homozygote
- Humans
- Male
- Middle Aged
- Mutation
- Myocardial Infarction
(genetics)
- Myocardial Ischemia
(genetics)
- Regression Analysis
- Risk Factors
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