The first total synthesis of (+/-)-linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells.

Abstract

[reaction in text] The first total synthesis of (+/-)-linderol A, a hexahydrodibenzofuran isolated from Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells was achieved via a 20-step of reaction in 7.64% overall yield starting from 4,6-dimethoxysalicylaldehyde.

• Authors: M Yamashita, N Ohta, I Kawasaki, S Ohta
• Journal: Organic letters (Org Lett) Vol. 3 Issue 9 Pg. 1359-62 (May 03 2001) ISSN: 1523-7060 [Print] United States
• PMID: 11348234 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzofurans
• Biological Products
• Melanins
• linderol A

Topics

• Benzofurans (chemical synthesis, chemistry, pharmacology)
• Biological Products (chemical synthesis, chemistry, pharmacology)
• Catalysis
• Isomerism
• Melanins (biosynthesis)
• Melanoma, Experimental (metabolism)
• Molecular Structure
• Plants, Medicinal (chemistry)
• Stereoisomerism
• Structure-Activity Relationship
• Tumor Cells, Cultured (drug effects)