Anticonvulsant activity of p-chlorophenyl substituted arylsemicarbazones--the role of primary terminal amino group.

A series of p-chlorophenyl substituted arylsemicarbazones were synthesized and evaluated for anticonvulsant activity. Most of the compounds provided significant protection against maximal electroshock-induced seizures (MES) at 100 mg/kg after 0.5 h and at 300 mg/kg after 4 h in both MES and pentetrazole-induced (PTZ) seizures. In the strychnine-induced seizures (scSTY), the majority of the compounds showed protection at 30 mg/kg. The compound 2 was active in both MES and PTZ tests. The study has shown that the terminal primary amino group is not necessary for anticonvulsant activity.
AuthorsS N Pandeya, V Mishra, I Ponnilavarasan, J P Stables
JournalPolish journal of pharmacology (Pol J Pharmacol) 2000 Jul-Aug Vol. 52 Issue 4 Pg. 283-90 ISSN: 1230-6002 [Print] Poland
PMID11345484 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Convulsants
  • Semicarbazones
  • Strychnine
  • Pentylenetetrazole
  • Animals
  • Anticonvulsants (chemical synthesis, chemistry, pharmacology)
  • Convulsants
  • Electroshock
  • Hydrogen Bonding
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Pentylenetetrazole
  • Postural Balance (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Seizures (chemically induced, prevention & control)
  • Semicarbazones (chemical synthesis, chemistry, pharmacology)
  • Spectrophotometry, Infrared
  • Structure-Activity Relationship
  • Strychnine

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