Radiomodification effects of Ukrain, a cytostatic and immunomodulating drug, on intracellular glucocorticoid reception during short-term gamma-irradiation.

Abstract

The ability of Ukrain, a cytostatic and immunomodulating semisynthetic compound of thiophosphate-modified alkaloids of Chelidonium majus L., to modify the effects of irradiation on intracellular glucocorticoid reception in female rat liver was evaluated after intraperitoneal administration of the drug at 0.4 mg/kg of body weight. Ukrain caused the normalization of the intracellular glucocorticoid-receptor system, influenced by short-term whole-body gamma-irradiation of rats with 1 Gy, beginning on the 10th day after administration of the drug. It was found that Ukrain minimized the consequences of irradiation in the endocrine system of the experimental animals.

• Authors: G L Luksa-Lichtenthaeler, E I Ladutko, J W Nowicky
• Journal: Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 26 Issue 5-6 Pg. 311-5 ( 2000) ISSN: 0378-6501 [Print] Switzerland
• PMID: 11345044 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Alkaloids
• Antineoplastic Agents, Phytogenic
• Berberine Alkaloids
• Glucocorticoids
• Phenanthridines
• Radiation-Protective Agents
• Receptors, Glucocorticoid
• ukrain
• Dexamethasone
• DNA

Topics

• Adjuvants, Immunologic (pharmacology)
• Alkaloids (pharmacology)
• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Berberine Alkaloids
• Body Weight (drug effects)
• Cell Nucleus (drug effects, metabolism, radiation effects)
• Cytosol (drug effects, metabolism, radiation effects)
• DNA (biosynthesis)
• Dexamethasone (metabolism)
• Female
• Glucocorticoids (pharmacology)
• Liver (drug effects, metabolism, radiation effects)
• Phenanthridines
• Radiation-Protective Agents (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Glucocorticoid (drug effects, radiation effects)