HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Paraneoplastic syndromes associated with anti-Hu antibodies.

Abstract
Paraneoplastic syndromes are disorders associated with cancer but without a direct effect of the tumor mass or its metastases on the nervous system. Small cell carcinoma of lung associated with paraneoplastic sensory neuronopathy and/or paraneoplastic encephalomyelitis with the presence of anti-Hu antibodies has been termed "anti-Hu syndrome." Anti-Hu associated PSN-PEM is an immune disorder in which both cell-mediated and humoral mechanisms are involved. Patients are considered affected by Anti-Hu associated PSN-PEM when they develop clinical signs and symptoms of CNS dysfunction and/or sensory neuropathy not caused by metastases or other disorders, and serum or cerebrospinal fluid is positive for Hu abs. SCLC is found in more than 90% of patients with cancer and positive Hu abs. Individual patients with Hu abs associated to SCLC may suffer PSN-PEM, limbic encephalitis, brainstem encephalopathy, opsoclonus-myoclonus, paraneoplastic cerebellar degeneration or myelopathy. Hu abs have a specificity of 99% and sensitivity of 82% in detecting paraneoplastic neurological syndromes. There are two types of treatment: the first is to treat the cancer, the second is to suppress the immune reaction with the use of corticosteroids, cyclophosphamide, azathioprine, plasma exchange, intravenous immunoglobulin and immunoadsorption; however, treatment of paraneoplastic syndromes is generally unsatisfactory.
AuthorsH Senties-Madrid, F Vega-Boada
JournalThe Israel Medical Association journal : IMAJ (Isr Med Assoc J) Vol. 3 Issue 2 Pg. 94-103 (Feb 2001) ISSN: 1565-1088 [Print] Israel
PMID11344832 (Publication Type: Journal Article, Review)
Chemical References
  • Antibodies, Antinuclear
  • HLA-D Antigens
  • Oncogene Proteins
Topics
  • Antibodies, Antinuclear (analysis)
  • Antibody Formation (physiology)
  • Comorbidity
  • Female
  • HLA-D Antigens (analysis, immunology)
  • Humans
  • Immunity (physiology)
  • Male
  • Neoplasms (epidemiology, immunology)
  • Oncogene Proteins (analysis, immunology)
  • Paraneoplastic Syndromes (epidemiology, immunology)
  • Sensitivity and Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: