Abstract | BACKGROUND AND OBJECTIVES: METHODS: RESULTS: All 93 patients received 3 perioperative doses of prophylactic intravenous antibiotics. One group (n=47) of patients also received intraoperative intracavitary instillation of an antibiotic solution ( penicillin G: 5 million units, bacitracin: 50,000 units, gentamicin: 60 mg, in 1 litre of saline) while the other group (n=46) did not. Age, gender, diagnosis, and length of stay were not significantly different in the two groups. There were no empyemas or bronchial fistulas in the intracavitary antibiotic group. Postpneumonectomy empyemas occurred in 6 (13%) patients ( empyema with bronchial fistula: 5, empyema alone: 1) that had not received intracavitary antibiotics (p=0.012). There were 4 deaths (9%) in each group (p=0.63). CONCLUSIONS: Prophylactic intraoperative intracavitary antibiotic instillation may reduce the incidence of empyemas after pneumonectomy. However, a randomized trial would be needed to prove the effectiveness of this form of prophylactic antibiotic strategy.
|
Authors | J D Miller, J Nemni, C Simone, J E Young, W F Bennett, J D Urschel |
Journal | Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
(Ann Thorac Cardiovasc Surg)
Vol. 7
Issue 1
Pg. 14-6
(Feb 2001)
ISSN: 1341-1098 [Print] Japan |
PMID | 11343560
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Gentamicins
- Bacitracin
- Penicillin G
|
Topics |
- Aged
- Antibiotic Prophylaxis
- Bacitracin
(administration & dosage, therapeutic use)
- Bronchial Fistula
(prevention & control)
- Empyema, Pleural
(prevention & control)
- Female
- Gentamicins
(administration & dosage, therapeutic use)
- Humans
- Instillation, Drug
- Length of Stay
- Male
- Middle Aged
- Penicillin G
(administration & dosage, therapeutic use)
- Pneumonectomy
- Retrospective Studies
|