AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9.

Abstract

The integrin alphaVbeta6 is a fibronectin receptor, which is not detectable on normal epithelium but is neo-expressed in oral epithelial dysplasia and oral squamous-cell carcinoma (SCC), suggesting a role in promoting malignant behaviour and tumour progression. We used transfection and retroviral infection to create a panel of SCC cell lines expressing various levels of alphaVbeta6 to examine this possibility. We found that increased expression of alphaVbeta6 in malignant keratinocytes up-regulates MMP-9 and MMP-2 expression and promotes invasion in an MMP-9-dependent manner. Our results suggest a possible mechanism for the involvement of alphaVbeta6 in squamous carcinoma in vivo.

• Authors: G J Thomas, M P Lewis, I R Hart, J F Marshall, P M Speight
• Journal: International journal of cancer (Int J Cancer) Vol. 92 Issue 5 Pg. 641-50 (Jun 01 2001) ISSN: 0020-7136 [Print] United States
• PMID: 11340566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Chemical References

• Antigens, Neoplasm
• Integrins
• integrin alphavbeta6
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Animals
• Antigens, Neoplasm
• Carcinoma, Squamous Cell (enzymology, pathology)
• Cell Line
• Cell Movement
• Enzyme Activation
• Integrins (analysis, physiology)
• Matrix Metalloproteinase 2 (analysis, biosynthesis)
• Matrix Metalloproteinase 9 (biosynthesis)
• Mice
• Mouth Neoplasms (enzymology, pathology)
• Neoplasm Invasiveness
• Transfection