Comparisons of intraocular-pressure- lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide.

Abstract

Forty-one healthy volunteers were recruited for a study to compare the intraocular pressure (IOP)-lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide. In a randomized double-blind design, one eye received one drop of 2% dorzolamide and the other eye received one drop of 1% brinzolamide. The IOP and side effects were evaluated by Goldmann applanation tonometry and slit lamp biomicroscopy before administration, and 3, 7 and 14 days after the initial administration of eyedrops. The IOP decreased significantly from baseline for both drugs (p < 0.05). However, there were no statistically significant differences between 2% dorzolamide and 1% brinzolamide either before or after eyedrop administration (p > 0.05). The most frequent side effect was ocular pain in the case of 2% dorzolamide and blurred vision in 1% brinzolamide. The results suggested that 2% dorzolamide and 1% brinzolamide have similar IOP-lowering efficacies with different side effects

• Authors: G J Seong, S C Lee, J H Lee, Y K Chu, Y J Hong
• Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde (Ophthalmologica) 2001 May-Jun Vol. 215 Issue 3 Pg. 188-91 ISSN: 0030-3755 [Print] Switzerland
• PMID: 11340389 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 S. Karger AG, Basel

Chemical References

• Carbonic Anhydrase Inhibitors
• Ophthalmic Solutions
• Sulfonamides
• Thiazines
• Thiophenes
• brinzolamide
• dorzolamide

Topics

• Adult
• Carbonic Anhydrase Inhibitors (adverse effects, pharmacology)
• Double-Blind Method
• Female
• Humans
• Intraocular Pressure (drug effects)
• Male
• Ophthalmic Solutions
• Safety
• Sulfonamides (adverse effects, pharmacology)
• Thiazines (adverse effects, pharmacology)
• Thiophenes (adverse effects, pharmacology)
• Tonometry, Ocular