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Baker's asthma due to xylanase and cellulase without sensitization to alpha-amylase and only weak sensitization to flour.

AbstractBACKGROUND:
The baking additives xylanase and cellulase were described as baking additives causing baker's asthma. It is not known whether monosensitization to these enzymes may occur.
METHODS:
We present a case report of a baker with work-related asthma evaluated by skin prick test (SPT), enzyme-linked immunosorbent assay (EAST), immunoblot, EAST and immunoblot inhibition, and specific bronchial challenge. Fungal xylanase and alpha-amylase were measured by two-site enzyme immunoassays in products used by the patient at work.
RESULTS:
Allergy to xylanase and cellulase was demonstrated by SPT, EAST, immunoblot and specific bronchial challenge (for xylanase only). No sensitization to alpha-amylase could be demonstrated, but there was a weak flour allergy as documented by EAST and immunoblot and a positive occupational-type challenge with high concentrations of rye flour. Four baking additives contained measurable amounts of fungal alpha-amylase and xylanase, without a correlation between these enzymes.
CONCLUSIONS:
We conclude that occupational asthma due to the baking additives xylanase and cellulase may occur without concomitant sensitization to alpha-amylase and only weak sensitization to flour.
AuthorsR Merget, I Sander, M Raulf-Heimsoth, X Baur
JournalInternational archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 124 Issue 4 Pg. 502-5 (Apr 2001) ISSN: 1018-2438 [Print] Switzerland
PMID11340334 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2001 S. Karger AG, Basel
Chemical References
  • Food Additives
  • Immunoglobulin E
  • Xylosidases
  • alpha-Amylases
  • Xylan Endo-1,3-beta-Xylosidase
  • Cellulase
Topics
  • Adult
  • Asthma (etiology, immunology)
  • Cellulase (adverse effects, analysis)
  • Cooking
  • Flour (adverse effects, analysis)
  • Food Additives (adverse effects, analysis)
  • Humans
  • Immunoglobulin E (immunology)
  • Male
  • Occupational Diseases (etiology, immunology)
  • Xylan Endo-1,3-beta-Xylosidase
  • Xylosidases (adverse effects, analysis)
  • alpha-Amylases (adverse effects, analysis)

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