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A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark.

Abstract
Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
AuthorsA Malheiros, V C Filho, C B Schmitt, Santos ARS, C Scheidt, J B Calixto, F D Monache, R A Yunes
JournalPhytochemistry (Phytochemistry) Vol. 57 Issue 1 Pg. 103-7 (May 2001) ISSN: 0031-9422 [Print] England
PMID11336250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • drimane
Topics
  • Analgesics (pharmacology)
  • Magnetic Resonance Spectroscopy
  • Magnoliopsida (chemistry)
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes (chemistry, pharmacology)
  • Spectrum Analysis

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