Abstract | OBJECTIVES: MATERIAL & METHODS: The study included 20 metastatic breast cancer patients, who were treated with taxotere (100 mg/mq I.V. every 21 days) for at least 3 consecutive cycles. Serum levels of PRL were measured by RIA before the onset of treatment and at 21-days intervals. RESULTS: The clinical response consisted of partial response (PR) in 6, stable disease (SD) in 7 and progressive disease (PD) in the remaining 7 patients. Abnormally high pre-treatment levels of PRL were seen in 7/20 patients. The percent of patients who had PD in response to chemotherapy was significantly high in patients with pre-treatment hyperprolactinemia than in those with normal blood levels of PRL before therapy. CONCLUSIONS: This study shows that the evidence of abnormally high serum levels of PRL correlates with resistance to chemotherapy with taxanes in metastatic breast cancer. Therefore, a concomitant administration of anti-prolactinemic agents, such as bromocriptine, could enhance the efficacy of chemotherapy itself.
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Authors | P Lissoni, M Vaghi, A Ardizzoia, E Fumagalli, G Tancini, G Gardani, A Conti, G J Maestroni |
Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 22
Issue 1
Pg. 27-9
( 2001)
ISSN: 0172-780X [Print] Sweden |
PMID | 11335876
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Biomarkers, Tumor
- Taxoids
- Docetaxel
- Prolactin
- Paclitaxel
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Topics |
- Adult
- Aged
- Antineoplastic Agents, Phytogenic
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Biomarkers, Tumor
(blood)
- Bone Neoplasms
(secondary)
- Breast Neoplasms
(blood, complications, drug therapy, pathology)
- Disease Progression
- Docetaxel
- Female
- Humans
- Hyperprolactinemia
(diagnosis, etiology)
- Injections, Intravenous
- Liver Neoplasms
(secondary)
- Lung Neoplasms
(secondary)
- Middle Aged
- Paclitaxel
(administration & dosage, analogs & derivatives)
- Prolactin
(blood)
- Remission Induction
- Taxoids
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