HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prevention of growth of human lung carcinoma cells and induction of apoptosis by a novel phenoxazinone, 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one.

Abstract
Anti-tumor effects of a novel phenoxazinone, 2-amino-4,4-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one (Phx), which was synthesized by the reaction of 2-amino-5-methylphenol with bovine hemoglobin, were studied in terms of suppression of the proliferation of human lung carcinoma cells and apoptosis induction. When Phx was added to cultures of the human lung carcinoma cell lines A549 (adenocarcinoma) and H226 (squamous carcinoma), it caused the growth inhibition and the death of these cells. Phx also fragmented the DNA of these cells to oligonucleosomal-sized fragments, which is characteristic of the apoptosis, dependent on the dose and exposure time. The cellular death caused by the administration of Phx was partially reversed by the addition of Z-VAD-fmk, a caspase family inhibitor. Present results suggest that Phx demonstrates anti-cancer activity against human lung carcinoma cell lines A549 and H226, by inhibiting growth and inducing apoptosis.
AuthorsA Abe, M Yamane, A Tomoda
JournalAnti-cancer drugs (Anticancer Drugs) Vol. 12 Issue 4 Pg. 377-82 (Apr 2001) ISSN: 0959-4973 [Print] England
PMID11335795 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one
  • Antineoplastic Agents
  • Caspase Inhibitors
  • Oxazines
Topics
  • Adenocarcinoma (drug therapy, pathology)
  • Antineoplastic Agents (administration & dosage)
  • Apoptosis (drug effects)
  • Carcinoma, Squamous Cell (drug therapy, pathology)
  • Caspase Inhibitors
  • Cell Division (drug effects)
  • Cell Survival (drug effects)
  • DNA Fragmentation (drug effects)
  • Dose-Response Relationship, Drug
  • Humans
  • Lung Neoplasms (drug therapy, pathology)
  • Oxazines (administration & dosage)
  • Tumor Cells, Cultured

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: