Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: Thirteen patients were entered on trial. BAY 12-9566 was well tolerated, with only one grade 3 headache, one grade 3 anemia, one grade 3 thrombocytopenia, and no musculoskeletal effects. The median treatment duration was 57 days (range 7-560). Mean trough levels of BAY 12-9566 on day 28 ranged from 80.5 to 108.6 mg/l. Plasma trough levels were 1500-42,000-fold above the Ki's for MMP-2, MMP-3, and MMP-9 at the 800 mg p.o. b.i.d. dose level. There was no significant change in VEGF, bFGF, pyridinoline, and deoxypyridinoline crosslinks with BAY 12-9566 administration. CONCLUSIONS: The recommended dose for further testing is 800 mg p.o. b.i.d.
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Authors | C Erlichman, A A Adjei, S R Alberts, J A Sloan, R M Goldberg, H C Pitot, J Rubin, P J Atherton, G G Klee, R Humphrey |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 12
Issue 3
Pg. 389-95
(Mar 2001)
ISSN: 0923-7534 [Print] England |
PMID | 11332153
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amino Acids
- Antineoplastic Agents
- Biphenyl Compounds
- Endothelial Growth Factors
- Enzyme Inhibitors
- Lymphokines
- Matrix Metalloproteinase Inhibitors
- Organic Chemicals
- Phenylbutyrates
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Fibroblast Growth Factor 2
- pyridinoline
- deoxypyridinoline
- Bay 12-9566
- Matrix Metalloproteinases
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Topics |
- Adult
- Amino Acids
(metabolism)
- Antineoplastic Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Biphenyl Compounds
- Dose-Response Relationship, Drug
- Endothelial Growth Factors
(metabolism)
- Enzyme Inhibitors
(administration & dosage, pharmacokinetics, therapeutic use)
- Female
- Fibroblast Growth Factor 2
(metabolism)
- Humans
- Lymphokines
(metabolism)
- Male
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(blood)
- Maximum Tolerated Dose
- Middle Aged
- Neoplasms
(drug therapy, enzymology)
- Organic Chemicals
- Phenylbutyrates
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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