[Effects of topical prostaglandin analogues on the aqueous flare intensity in rabbit eyes at an early phase of endotoxin-induced uveitis].

Abstract

PURPOSE:

We examined the effects of prostaglandin analogues on the blood-aqueous barrier(BAB) permeability in rabbit eyes at an early phase of endotoxin-induced uveitis(EIU).

SUBJECTS AND METHODS:

One drop of 0.005% latanoprost or 0.12% unoprostone were applied to rabbit eyes. Escherichia coli lipopolysaccharides were injected to induce uveitis. The changes in flare intensity in normal eyes and EIU eyes after application of eye drops were evaluated. The effect of cyclooxygenase inhibitor on the flare intensity changes caused by the application of unoprostone was also examined.

RESULTS:

Flare intensity increased significantly after a single instillation of unoprostone, and the increase was not prevented by pretreatment with cyclooxygenase inhibitor. In eyes with EIU, unoprostone caused an additional increase of flare intensity to uveitis induced flare change. Latanoprost had no effects on BAB in eyes with normal and with uveitic conditions.

CONCLUSION:

Latanoprost and unoprostone did not cause an excessive inflammatory reaction in rabbit eyes at an early phase of EIU.

• Authors: Y Kiuchi, H Itaya, Y Shiotani, K Nakae, I Ishimoto, Y Hori, S Sato, K Fukui, M Kubo, Y Hayashida, T Ohnishi, Y Tsukamoto, J Morioka
• Journal: Nippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 105 Issue 4 Pg. 230-6 (Apr 2001) ISSN: 0029-0203 [Print] Japan
• PMID: 11329946 (Publication Type: Journal Article)

Chemical References

• Prostaglandins F, Synthetic
• isopropyl unoprostone
• Latanoprost
• Dinoprost

Topics

• Animals
• Blood-Aqueous Barrier (drug effects)
• Dinoprost (analogs & derivatives, pharmacology)
• Female
• Latanoprost
• Male
• Prostaglandins F, Synthetic (pharmacology)
• Rabbits
• Uveitis (chemically induced, physiopathology)