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Losigamone add-on therapy in partial epilepsy: a placebo-controlled study.

AbstractOBJECTIVES:
To evaluate the efficacy and tolerability of losigamone (LSG).
PATIENTS AND METHODS:
Double-blind, placebo-controlled add-on study with 3x500 mg LSG/die for the treatment of chronic partial seizures in 203 patients (99 treated with LSG, 104 on placebo).
RESULTS:
The median percent change of seizures was 14.9% (LSG) versus 6.7% (placebo) (P=0.004). Seizure frequency was decreased by more than 50% in 22.3% (LSG) and 14.6% (placebo) of patients (P=0.13). Mean percent change of seizures was best in patients with only one additional anticonvulsant drug (LSG versus placebo, P=0.004). Adverse events (usually CNS-related side effects of mild to moderate intensity) were reported in 59.6% (LSG) and 37.5% (placebo) of patients.
CONCLUSIONS:
LSG proved to be an effective and well tolerated anticonvulsant drug for the treatment of chronic partial seizures.
AuthorsJ Bauer, A Dienel, C E Elger, Losigamone Study Group
JournalActa neurologica Scandinavica (Acta Neurol Scand) Vol. 103 Issue 4 Pg. 226-30 (Apr 2001) ISSN: 0001-6314 [Print] Denmark
PMID11328193 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anticonvulsants
  • Furans
  • losigame
Topics
  • Adolescent
  • Adult
  • Anticonvulsants (therapeutic use)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Epilepsies, Partial (drug therapy)
  • Female
  • Furans (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome

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