New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice.

Abstract

Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or Commiphora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect on exudative pouch fluid, angiogenesis, and granuloma weights in adjuvant-induced air-pouch granuloma of mice. Its effects were more marked than those of hydrocortisone and the 50% aqueous methanolic extract of the crude drug. Myrrhanol A is a plausible candidate for a potent anti-inflammatory agent.

• Authors: I Kimura, M Yoshikawa, S Kobayashi, Y Sugihara, M Suzuki, H Oominami, T Murakami, H Matsuda, V V Doiphode
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 11 Issue 8 Pg. 985-9 (Apr 23 2001) ISSN: 0960-894X [Print] England
• PMID: 11327606 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Plant Extracts
• Plant Gums
• Terpenes
• Triterpenes
• myrrhanol A
• myrrhanone A
• guggulu extract
• Freund's Adjuvant
• Carmine
• myrrh oil

Topics

• Animals
• Anti-Inflammatory Agents (chemistry, pharmacology, therapeutic use)
• Carmine (analysis)
• Cell Movement (drug effects)
• Commiphora
• Dose-Response Relationship, Drug
• Exudates and Transudates (drug effects)
• Freund's Adjuvant
• Granuloma (chemically induced, drug therapy)
• Male
• Mice
• Neovascularization, Pathologic (drug therapy)
• Plant Extracts (chemistry)
• Plant Gums
• Terpenes (pharmacology, therapeutic use)
• Triterpenes (chemical synthesis, chemistry, pharmacology, therapeutic use)