The efficacy of Xialine in patients with xerostomia resulting from radiotherapy for head and neck cancer: a pilot-study.

Abstract	Changes in subjective sensations due to xerostomia before and after administration of Xialine, a xanthan gum-based saliva substitute, were evaluated in 30 patients with radiation-induced xerostomia using the QLQ-H&N35. Xerostomia in general decreased with both Xialine and placebo to almost the same degree. A trend was seen for Xialine to improve problems with speech and senses.
Authors	A P Jellema, H Langendijk, L Bergenhenegouwen, W van der Reijden, R Leemans, L Smeele, B J Slotman
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 59 Issue 2 Pg. 157-60 (May 2001) ISSN: 0167-8140 [Print] Ireland
PMID	11325444 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References	Polysaccharides, Bacterial Saliva, Artificial xialine xanthan gum
Topics	Aged Chi-Square Distribution Cross-Over Studies Double-Blind Method Female Head and Neck Neoplasms (radiotherapy) Humans Male Middle Aged Pilot Projects Polysaccharides, Bacterial (therapeutic use) Radiotherapy (adverse effects) Saliva, Artificial (therapeutic use) Surveys and Questionnaires Xerostomia (drug therapy, etiology)

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