A transient increase in CCK mRNA levels in hippocampus following audiogenic convulsions in audiogenic seizure-prone rats.

Abstract

AIM:

To examine the effects of a single convulsion and multiple convulsions on cholecystokinin (CCK) mRNA expression in hippocampus of audiogenic seizure-prone rats (P77PMC).

METHODS:

Ringing (electric bell, 100 dB, 60 s) was used to induce convulsions, hippocampal CCK mRNA expression was exhibited by in situ hybridization.

RESULTS:

1) The number of CCK mRNA-positive neurons in principal hippocampus of normal rats was 34 +/- 5, which elevated markedly after a single (155 +/- 7, P < 0.01) or multiple convulsions (95 +/- 8, P < 0.01). 2) CCK mRNA levels in multiple consecutive convulsion rats were lower than that in a single convulsion rats (P < 0.01).

CONCLUSION:

The increased number of CCK mRNA-positive neurons in hippocampus may have important functional consequences in convulsion-associated processes.

• Authors: H Ni, Z H Lu, S B Wang, M Tang
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 21 Issue 5 Pg. 425-8 (May 2000) ISSN: 1671-4083 [Print] United States
• PMID: 11324440 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• Cholecystokinin

Topics

• Acoustic Stimulation
• Animals
• Cholecystokinin (biosynthesis, genetics)
• Epilepsy, Reflex (metabolism)
• Hippocampus (metabolism)
• In Situ Hybridization
• Neurons (metabolism)
• RNA, Messenger (biosynthesis, genetics)
• Random Allocation
• Rats