The potential of radioiodinated (-)-m-iodovesamicol for diagnosing cholinergic deficit dementia.

Abstract

We investigated changes in the brain distribution of (-)-[(125)I]-m-iodovesamicol [(-)-[(125)I]mIV] in cholinergic denervation rats produced by a unilateral lesion of the nucleus basalis magnocellularis (NBM). Dual-tracer ex vivo autoradiographic analysis using (-)-[(125)I]mIV and [(99m)Tc]HMPAO was conducted to the effect of regional cerebral perfusion on the brain distribution of (-)-[(125)I]mIV in a unilateral NBM-lesioned rat. (-)-[(125)I]mIV binding in the ipsilateral cortex to the lesion significantly reduced by 10.4 %, compared with that in the contralateral cortex, while (-)-[(125)I]mIV binding in the ipsilateral caudate putamen, hippocampus and thalamus did not change. The rate of reduction in the (-)-[(125)I]mIV binding (10.4 %) was significantly higher than that of [(99m)Tc]HMPAO accumulation (4.0%) in the ipsilateral cortex to the lesion (P < 0.01). These results suggested that radioiodinated (-)-mIV may be useful in the study of dementia characterized by degeneration of the cholinergic neurotransmitter system, such as Alzheimer's disease.

• Authors: K Shiba, H Mori, E Ikeda, H Sumiya, N Tonami
• Journal: Nuclear medicine and biology (Nucl Med Biol) Vol. 28 Issue 3 Pg. 261-4 (Apr 2001) ISSN: 0969-8051 [Print] United States
• PMID: 11323235 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Piperidines
• 3-iodovesamicol
• Technetium Tc 99m Exametazime
• Acetylcholine

Topics

• Acetylcholine (deficiency)
• Animals
• Autoradiography
• Brain (diagnostic imaging, metabolism)
• Dementia (diagnostic imaging, metabolism)
• Male
• Piperidines (pharmacokinetics)
• Radionuclide Imaging
• Rats
• Rats, Sprague-Dawley
• Technetium Tc 99m Exametazime
• Tissue Distribution