Abstract | BACKGROUND: METHODS: RESULTS: The average total esterified F2-isoprostanes in the ESRD patients was 1.62 +/- 0.73 vs. 0.27 +/- 0.10 ng/mL in controls (P < 0.001), with no overlap between patients and controls. Plasma F2-isoprostanes in diabetic ESRD patients were similar to F2-isoprostanes in patients with other causes for renal failure. In a subset of 10 of these ESRD patients evaluated eight months after the initial measurement, plasma-esterified F2-isoprostanes were not altered by an individual dialysis session. Average plasma CRP values were also higher in HD patients (P < 0.02), but some patients had CRP values that were similar to controls. In the HD patients, total plasma F2-isoprostanes and plasma CRP were correlated (r = 0.48, P = 0.015). Plasma alpha-tocopherol did not differ between patients and controls, but plasma retinol was higher in patients (3.15 +/- 1.71 micromol/L) than in controls (1.97 +/- 0.51 micromol/L, P < 0.05). CONCLUSIONS: These results are consistent with the hypothesis that oxidative stress in ESRD patients contributes to increased values of esterified plasma F2-isoprostanes, with concurrent increases in plasma CRP levels in some patients. Impaired clearance of esterified F2-isoprostanes may contribute to the elevated levels in renal failure. Plasma esterified F2-isoprostanes may be a useful indicator to evaluate effectiveness of interventions to decrease oxidative stress and associated inflammation.
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Authors | G J Handelman, M F Walter, R Adhikarla, J Gross, G E Dallal, N W Levin, J B Blumberg |
Journal | Kidney international
(Kidney Int)
Vol. 59
Issue 5
Pg. 1960-6
(May 2001)
ISSN: 0085-2538 [Print] United States |
PMID | 11318969
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- F2-Isoprostanes
- Vitamin A
- Vitamin E
- C-Reactive Protein
- Dinoprost
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Topics |
- Aged
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Dinoprost
(analogs & derivatives, blood, chemistry)
- Esterification
- F2-Isoprostanes
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Middle Aged
- Oxidative Stress
- Renal Dialysis
(adverse effects)
- Vitamin A
(blood)
- Vitamin E
(blood)
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