Abstract | AIMS: METHODS AND RESULTS: The lining epithelium in 22 cases of odontogenic keratocyst, 26 cases of residual cyst and 20 cases of dentigerous cyst were examined for the expression of calretinin. No positive epithelial staining was observed in any of these cystic lesions. In comparison, however, 81.5% of cases of unicystic ameloblastoma showed a coarse dark brown staining of the more superficial epithelial cell layers. Scattered positive stromal and epithelial cells were present; these were interpreted as mast cells. CONCLUSIONS:
Calretinin appears to be a specific immunohistochemical marker for neoplastic ameloblastic epithelium and we suggest that it may be an important diagnostic aid in the differential diagnosis of cystic odontogenic lesions and ameloblastic tumours.
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Authors | H Coleman, M Altini, H Ali, C Doglioni, G Favia, E Maiorano |
Journal | Histopathology
(Histopathology)
Vol. 38
Issue 4
Pg. 312-7
(Apr 2001)
ISSN: 0309-0167 [Print] England |
PMID | 11318896
(Publication Type: Evaluation Study, Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- CALB2 protein, human
- Calbindin 2
- S100 Calcium Binding Protein G
|
Topics |
- Ameloblastoma
(diagnosis)
- Ameloblasts
(cytology)
- Biomarkers, Tumor
(analysis)
- Calbindin 2
- Dentigerous Cyst
(diagnosis)
- Diagnosis, Differential
- Humans
- Immunohistochemistry
- Jaw Neoplasms
(diagnosis)
- Odontogenic Cysts
(diagnosis)
- S100 Calcium Binding Protein G
(analysis)
- Sensitivity and Specificity
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