HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunodetectable cyclin D(1)is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions.

Abstract
Cyclin D1 is associated with cell cycle regulation and has more recently been shown to stimulate the transcriptional functions of the oestrogen receptor (ER). Furthermore, in normal breast there is a negative association between expression of ER and the proliferation marker Ki67 indicating that either ER positive cells are non-dividing or that the receptor is down-regulated as cells enter cycle. This important relationship breaks down in many ER-positive cancers and precancerous breast lesions where the receptor is often detected on proliferating cells. The aims of the present study were to determine the interplay between ER, Ki67 and cyclin D(1)in individual cells within the spectrum of human breast lesions ranging from normal to invasive carcinoma by using dual staining immunofluorescence. We found that in normal breast there was a strong positive association between ER and cyclin D(1)expression. In contrast there was a strong negative association between cyclin D(1)and Ki67 expression. Similar findings were seen for the other precancerous and cancerous breast lesions. Thus immunodetectable cyclin D(1)within individual cells does not appear to be associated with cell cycle progression in the benign or malignant breast but instead may have important interactions with ER.
AuthorsB S Shoker, C Jarvis, M P Davies, M Iqbal, D R Sibson, J P Sloane
JournalBritish journal of cancer (Br J Cancer) Vol. 84 Issue 8 Pg. 1064-9 (Apr 20 2001) ISSN: 0007-0920 [Print] England
PMID11308255 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2001 Cancer Research Campaign.
Chemical References
  • Antibodies, Monoclonal
  • Ki-67 Antigen
  • Receptors, Estrogen
  • Cyclin D1
Topics
  • Antibodies, Monoclonal (analysis)
  • Antibody Specificity
  • Breast (chemistry, pathology)
  • Breast Neoplasms (metabolism, pathology)
  • Cyclin D1 (analysis)
  • Humans
  • Hyperplasia (metabolism, pathology)
  • Immunohistochemistry
  • Ki-67 Antigen (analysis)
  • Mitosis
  • Neoplasm Invasiveness
  • Precancerous Conditions (metabolism, pathology)
  • Receptors, Estrogen (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: