Abstract |
We have attempted to establish a systematic pathogenetic analysis of thrombophilia by including assays of antithrombin III(AT III), protein C(PC), protein S(PS), fibrinogen, plasminogen and heparin cofactor II by both functional and immunological methods as well as detecting lupus anticoagulants. Such a comprehensive scheme was instrumental in systematically identifying and confirming the pathogenesis of 164 cases which otherwise would have escaped detection since 1994 in our laboratory (Kyushu University Hospital). The analysis was conducted on 485 consecutive patients with venous thrombosis, arterial thrombosis and disorders in which small vessel thrombosis were implicated. Hundred and sixty four patients, (40% of the examined patients), were found to have low activities of PS, PC, ATIII etc. Among them, seventy five patients(46%) had low PS activity, and twenty nine(18%) had low PC activity. Genetic analyses performed on specimens with low PS/PC activities resulted in the confirmation of 24 genetic abnormalities. Such genetic abnormalities, however, does not solely lead to the pathogenesis of thromboses. We have found that some genetic polymorphisms, such as PS Tokushima, factor XII 46C allele, were also additional risk factors for thromboses.
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Authors | S Kinoshita, N Hamasaki |
Journal | Rinsho byori. The Japanese journal of clinical pathology
(Rinsho Byori)
Vol. 49
Issue 2
Pg. 165-71
(Feb 2001)
ISSN: 0047-1860 [Print] Japan |
PMID | 11307310
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Protein C
- Protein S
- Antithrombin III
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Topics |
- Antithrombin III
(genetics)
- Humans
- Polymorphism, Genetic
(immunology)
- Protein C
(genetics)
- Protein S
(genetics)
- Thrombosis
(genetics)
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