Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population.

Abstract

Ser326Cys polymorphism in the hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, has been identified and the variant genotype appears to be related to susceptibility to certain cancers. We investigated the association between Ser326Cys polymorphism and squamous-cell carcinoma of the esophagus among a Chinese population. hOGG1 gene polymorphism was detected by PCR-based single-strand conformation polymorphism and DNA sequencing among 201 normal controls and 196 patients with esophageal cancer from Linxian, China, a high-risk area for the disease. The association between this genetic polymorphism and risk of the cancer was examined by a multivariate analysis. We found that the distribution of hOGG1 Ser326Cys genotypes among controls (Ser/Ser, 33.8%; Ser/Cys, 52.8%; and Cys/Cys, 13.4%) was significantly different from that among esophageal cancer cases (39.8%, 38.8% and 21.4%, respectively) (p < 0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing esophageal squamous-cell carcinoma, with the odds ratio (OR) adjusted for age, sex and smoking being 1.9 (95% confidence interval [CI] = 1.3-2.6). Although smoking alone also significantly increased esophageal cancer risk in this case-control study (adjusted OR = 2.6; 95% CI = 1.7-3.9), no significant interaction between smoking and the Cys/Cys genotype was observed in terms of risk. Our results suggest that the hOGG1 326Cys allele might play a role in the carcinogenesis of the esophagus.

• Authors: D Y Xing, W Tan, N Song, D X Lin
• Journal: International journal of cancer (Int J Cancer) Vol. 95 Issue 3 Pg. 140-3 (May 20 2001) ISSN: 0020-7136 [Print] United States
• PMID: 11307145 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Chemical References

• Serine
• N-Glycosyl Hydrolases
• DNA-Formamidopyrimidine Glycosylase
• Cysteine

Topics

• Amino Acid Substitution
• Asian People (genetics)
• Cysteine (genetics)
• DNA-Formamidopyrimidine Glycosylase
• Esophageal Neoplasms (ethnology, genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Male
• Middle Aged
• N-Glycosyl Hydrolases (genetics)
• Polymorphism, Genetic
• Risk Factors
• Serine (genetics)