Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia.

Abstract

Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.

• Authors: H U Simon, S G Plötz, D Simon, R Dummer, K Blaser
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) 2001 Jan-Mar Vol. 124 Issue 1-3 Pg. 242-5 ISSN: 1018-2438 [Print] Switzerland
• PMID: 11306981 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 S. Karger AG, Basel

Chemical References

• Interleukin-5

Topics

• Clone Cells
• Eosinophils (pathology)
• Humans
• Hypereosinophilic Syndrome (immunology, pathology)
• Immunophenotyping
• Interleukin-5 (biosynthesis)
• Lymphocyte Subsets (classification)
• Lymphoma, T-Cell (etiology)
• Skin (pathology)
• T-Lymphocytes (immunology)