Assessment of myocardial postreperfusion viability by intravenous myocardial contrast echocardiography: analysis of the intensity and texture of opacification.

Abstract

BACKGROUND:

Although defects on intracoronary myocardial contrast echocardiography (MCE) indicate loss of viability after reperfusion, opacified segments may also exhibit persistent dyssynergy. Therefore, we related the intensity and texture of opacification produced by an intravenous contrast agent to histological findings to determine the characteristics of necrotic tissue by postreperfusion MCE.

METHODS AND RESULTS:

MCE was performed by intravenous injection of 0.15 mL/kg QW7437 in 14 dogs who underwent 3-hour coronary occlusion followed by 3-hour reperfusion. At baseline and 3 hours after reperfusion, midventricular short-axis images were digitized and segmented. Infarction fraction (IF) for each segment was determined by triphenyltetrazolium chloride stain. Of 224 segments, 140 showed no or small infarction and served as a control group. Of 84 segments with significant infarction (IF>30%), 52 exhibited a defect on MCE, and 32 exhibited no defect. Echo texture was quantified by computing entropy based on the co-occurrence matrix analysis of gray-level pairs within each segment. Three hours after reperfusion, average and maximal entropies in the infarct segments without opacification defects were significantly higher than control levels. Histologically, the degree of intracapillary erythrocyte stasis was less in this group than in the infarcted segments with MCE defects with similar magnitude of tissue injuries.

CONCLUSIONS:

Opacification defects by MCE may be present or absent in myocardium with histologically confirmed infarction. The texture of MCE from opacified but infarcted myocardium differed significantly from control segments and may assist in determination of segmental viability after reperfusion.

• Authors: K Ohmori, B Cotter, E Leistad, V Bhargava, P L Wolf, K Mizushige, A N DeMaria
• Journal: Circulation (Circulation) Vol. 103 Issue 15 Pg. 2021-7 (Apr 17 2001) ISSN: 1524-4539 [Electronic] United States
• PMID: 11306533 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Contrast Media
• Fluorocarbons
• QW7437

Topics

• Animals
• Contrast Media (administration & dosage)
• Coronary Disease (complications)
• Disease Models, Animal
• Dogs
• Echocardiography
• Electrocardiography
• Fluorocarbons (administration & dosage)
• Image Processing, Computer-Assisted
• Injections, Intravenous
• Myocardial Infarction (diagnosis, pathology)
• Myocardial Reperfusion
• Myocardium (pathology)
• Predictive Value of Tests
• Reperfusion Injury (diagnosis, pathology)