Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta.

Abstract

The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were investigated. Intravenous spiramine T (0.38, 0.75, and 1.5 mg.kg-1) markedly reduced the stroke index, enhanced the recovery of EEG amplitude during reperfusion and decreased the concentrations of cortex calcium and LPO in a dose-dependent manner. However, no significant effects on water and sodium contents were observed. These results suggested that spiramine T exhibited protective effects on cerebral ischemia-reperfusion injury in gerbils, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation. This is the first report on spiramine T as a natural product with neuroprotective effects.

• Authors: L Li, J Nie, Z Shen, W Wu, Z Chen, X Hao
• Journal: Planta medica (Planta Med) Vol. 67 Issue 2 Pg. 142-5 (Mar 2001) ISSN: 0032-0943 [Print] Germany
• PMID: 11301860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Heterocyclic Compounds, 4 or More Rings
• Lipid Peroxides
• Neuroprotective Agents
• spiramine T

Topics

• Animals
• Brain Ischemia (drug therapy)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drugs, Chinese Herbal (isolation & purification, pharmacology, therapeutic use)
• Female
• Gerbillinae
• Heterocyclic Compounds, 4 or More Rings (isolation & purification, pharmacology, therapeutic use)
• Lipid Peroxides (metabolism)
• Male
• Molecular Structure
• Neuroprotective Agents (isolation & purification, pharmacology, therapeutic use)
• Plant Roots (chemistry)
• Plants, Medicinal (chemistry)
• Reperfusion Injury (drug therapy)
• Rosacea