Anti-Ri-associated paraneoplastic opsoclonus-ataxia syndrome in a man with transitional cell carcinoma.

Abstract

BACKGROUND:

There are several case reports describing paraneoplastic syndromes in patients with various forms of bladder carcinoma. Current immunologic analyses have enabled the identification of the antineuronal autoantibodies associated with specific syndromes.

METHODS:

A patient with a history of bladder carcinoma presented with opsoclonus and myoclonus.

RESULTS:

Workup confirmed the presence of anti-Ri antibodies in the patient's serum and cerebrospinal fluid. The target Ri antigen was found to be expressed by the tumor.

CONCLUSIONS:

To the authors' knowledge, there are few reports in the literature describing the long-term clinical follow-up and postmortem evaluation in a patient with this form of paraneoplastic syndrome. More important, the authors believe the current study represents the first time that the presence of anti-Ri antibodies has been noted in a paraneoplastic syndrome associated with transitional cell carcinoma of the bladder.

• Authors: C J Prestigiacomo, C Balmaceda, J Dalmau
• Journal: Cancer (Cancer) Vol. 91 Issue 8 Pg. 1423-8 (Apr 15 2001) ISSN: 0008-543X [Print] United States
• PMID: 11301388 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright 2001 American Cancer Society.

Chemical References

• Antibodies
• Antigens, Neoplasm
• Nerve Tissue Proteins
• Neuro-Oncological Ventral Antigen
• RNA-Binding Proteins

Topics

• Antibodies
• Antigens, Neoplasm (immunology)
• Ataxia (etiology, pathology)
• Carcinoma, Transitional Cell (complications, immunology, pathology)
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Nerve Tissue Proteins
• Neuro-Oncological Ventral Antigen
• Ocular Motility Disorders (etiology, pathology)
• Paraneoplastic Syndromes (immunology, pathology)
• RNA-Binding Proteins
• Urinary Bladder Neoplasms (complications, immunology, pathology)