Abstract |
The specific sigma-receptor agonist (+)- SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)- SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lower concentrations of (+)- SKF 10047 did not disrupt memory formation. The amnesia produced by the efficacious dose of (+)- SKF 10047 was reversed by the specific antagonist, BD 1047. It is suggested that the sigma-receptor may exert its effect on passive-avoidance memory consolidation during the later stages of long-term memory formation by modulation of memory-related neurotransmission.
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Authors | F M Freeman, I G Young |
Journal | Neurobiology of learning and memory
(Neurobiol Learn Mem)
Vol. 75
Issue 3
Pg. 346-52
(May 2001)
ISSN: 1074-7427 [Print] United States |
PMID | 11300740
(Publication Type: Journal Article)
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Copyright | Copyright 2001 Academic Press. |
Chemical References |
- Antipsychotic Agents
- Ethylenediamines
- Receptors, sigma
- N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin
- SK&F 10047
- Phenazocine
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Topics |
- Amnesia
(chemically induced)
- Animals
- Animals, Newborn
- Antipsychotic Agents
(adverse effects, antagonists & inhibitors)
- Avoidance Learning
(drug effects)
- Chickens
- Ethylenediamines
(administration & dosage, pharmacology)
- Olfactory Bulb
(drug effects)
- Phenazocine
(adverse effects, analogs & derivatives, antagonists & inhibitors)
- Receptors, sigma
(antagonists & inhibitors, drug effects)
- Synaptic Transmission
(drug effects)
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