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Involvement of the sigma receptor in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.

Abstract
The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lower concentrations of (+)-SKF 10047 did not disrupt memory formation. The amnesia produced by the efficacious dose of (+)-SKF 10047 was reversed by the specific antagonist, BD 1047. It is suggested that the sigma-receptor may exert its effect on passive-avoidance memory consolidation during the later stages of long-term memory formation by modulation of memory-related neurotransmission.
AuthorsF M Freeman, I G Young
JournalNeurobiology of learning and memory (Neurobiol Learn Mem) Vol. 75 Issue 3 Pg. 346-52 (May 2001) ISSN: 1074-7427 [Print] United States
PMID11300740 (Publication Type: Journal Article)
CopyrightCopyright 2001 Academic Press.
Chemical References
  • Antipsychotic Agents
  • Ethylenediamines
  • Receptors, sigma
  • N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin
  • SK&F 10047
  • Phenazocine
Topics
  • Amnesia (chemically induced)
  • Animals
  • Animals, Newborn
  • Antipsychotic Agents (adverse effects, antagonists & inhibitors)
  • Avoidance Learning (drug effects)
  • Chickens
  • Ethylenediamines (administration & dosage, pharmacology)
  • Olfactory Bulb (drug effects)
  • Phenazocine (adverse effects, analogs & derivatives, antagonists & inhibitors)
  • Receptors, sigma (antagonists & inhibitors, drug effects)
  • Synaptic Transmission (drug effects)

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