Abstract |
In sarcoma 45 growth the concentration of all fractions of 11-oxycorticosteroids (11--OCS) was found to be increased. Maximum increase in concentration of total and bound 11--OCS was noted on the 7th and 10th day after transplantation. The content of total and bound 11 -- OCS on the 15th and 20th day of tumor growth was close to control values, however, the concentration of free 11 -- OCS exceeded the control level. At the 30th day of the experiment the values of total and bound 11 -- OCS were reliably decreased. While the free hormone content was within control limits. In a progressing malignant growth the binding capacity of transcortin is reduced up to 18.5% (the 30th day of the experiment) that makes 25% of the control value. The content of bound exogenic corticosterone in vitro ranged from 7.7 to 45.2 Mg% in the process of sarcorna 45 growth.
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Authors | K I Krauialis, A P Diashrius, A A Kershulis |
Journal | Voprosy onkologii
(Vopr Onkol)
Vol. 21
Issue 2
Pg. 67-70
( 1975)
ISSN: 0507-3758 [Print] Russia (Federation) |
Vernacular Title | Oksikortikosteroidy i sviazyvaiushchaia sposobnost' transkortina pri sarkome-45] |
PMID | 1130010
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- 11-Hydroxycorticosteroids
- Transcortin
|
Topics |
- 11-Hydroxycorticosteroids
(blood)
- Animals
- Male
- Protein Binding
- Rats
- Sarcoma, Experimental
(blood)
- Time Factors
- Transcortin
(metabolism)
|