A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura.

Treatment with 75 microg/kg/d intravenous (i.v.) anti-D was compared with 50 microg/kg/d in a prospective randomized study of 27 RhD-positive, human immunodeficiency virus-negative, adult, acute, non-splenectomized patients with immune thrombocytopenic purpura (ITP) and platelet counts < or = 30 x 109/l. The higher dose resulted in greater median d 1 (43 x 109/l vs. 7.5 x 109/l; P = 0.012) and d 7 (153 x 109/l vs. 64.5 x 109/l; P = 0.001) platelet increases despite no greater haemoglobin decrease. Children with acute ITP receiving 75 microg/kg/d had overnight platelet increases in seven out of nine cases. The duration of effect at the 75 microg/kg/d dose was 46 d vs. 21 d (P = 0.03). Adverse events were mild to moderate and ameliorated with prednisone and acetaminophen premedication.
AuthorsG C Newman, M V Novoa, E M Fodero, M L Lesser, B M Woloski, J B Bussel
JournalBritish journal of haematology (Br J Haematol) Vol. 112 Issue 4 Pg. 1076-8 (Mar 2001) ISSN: 0007-1048 [Print] England
PMID11298610 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Rho(D) Immune Globulin
  • Acetaminophen
  • Prednisone
  • Acetaminophen (therapeutic use)
  • Adult
  • Analgesics, Non-Narcotic (therapeutic use)
  • Anti-Inflammatory Agents (therapeutic use)
  • Child
  • Drug Administration Schedule
  • Humans
  • Infusions, Intravenous
  • Platelet Count
  • Prednisone (therapeutic use)
  • Premedication
  • Prospective Studies
  • Purpura, Thrombocytopenic (blood, therapy)
  • Rho(D) Immune Globulin (administration & dosage)
  • Statistics, Nonparametric

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