Anticonvulsant effects of 6-methoxy-1, 2, 3, 4-tetrahydro-alpha-carboline on audiogenic and electroconvulsive seizures in mice.

Abstract

6-Methoxy-1, 2, 3, 4, -tetrahydro-beta-carboline (6-MeO-THBC) was tested for anticonvulsant properties against audiogenic seizures in DBA/2J and primed C57BL/6J mice (i.e., mice given a prior auditory exposure) and aginast electroconvulsive seizures in DBA/2J mice. 6-MeO-THBC (100 mg/kg) was found to attenuate both types of behavioral seizures 2 hr after injection as compared to saline controls. In addition, 6-MeO-THBC increased whole brain serotonin and decreased whole brain 5-hydroxyindoleacetic acid 2 hr after injection. These results support previous reports which suggest a serotonergic involvement in behavioral seizures.

• Authors: N S Buckholtz
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) 1975 Jan-Feb Vol. 3 Issue 1 Pg. 65-8 ISSN: 0091-3057 [Print] United States
• PMID: 1129356 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants
• Carbolines
• Indoles
• Methyl Ethers
• Serotonin
• Hydroxyindoleacetic Acid

Topics

• Acoustic Stimulation
• Animals
• Anticonvulsants
• Behavior, Animal (drug effects)
• Brain (drug effects, metabolism)
• Carbolines (pharmacology, therapeutic use)
• Electroshock
• Female
• Hydroxyindoleacetic Acid (metabolism)
• Indoles (therapeutic use)
• Male
• Methyl Ethers (pharmacology, therapeutic use)
• Mice
• Mice, Inbred Strains
• Seizures (drug therapy)
• Serotonin (metabolism)
• Species Specificity
• Time Factors