Abstract | BACKGROUND: METHODS: We studied 8 patients with a history of systemic hypertension (6 females and 2 males, mean age 69+/-6 years), affected by New York Heart Association (NYHA) class IV congestive heart failure notwithstanding conventional drug therapy with digoxin, diuretic, and vasodilators. After clinical history and physical examination, blood chemistry including cardiac enzymes, arterial blood gases, chest roentgenogram, standard 12-lead ECG, and complete echocardiographic study were performed in all patients. RESULTS: In all cases, a left ventricle with increased wall thickness, normal cavity size, and normal or supernormal systolic function was shown. All patients had left ventricular systolic dynamic obstruction, with peak gradient between 36 and 130 mmHg (mean 83+/-31). After having stopped treatment with nitrates, digoxin, and diuretics, drug therapy with calcium channel antagonists or beta-blockers was started, and rapid clinical improvement with disappearance of left ventricular outflow obstruction was observed. CONCLUSIONS:
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Authors | A Sgreccia, G Morabito, A Gurgo Di Castelmenardo, M L Bernardo, A C Petrilli, R De Leva, P De Marzio, F Nuccio, S Morelli |
Journal | Minerva cardioangiologica
(Minerva Cardioangiol)
Vol. 49
Issue 2
Pg. 99-106
(Apr 2001)
ISSN: 0026-4725 [Print] Italy |
PMID | 11292953
(Publication Type: Journal Article)
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Topics |
- Aged
- Female
- Heart Failure
(etiology)
- Humans
- Hypertension
(complications, physiopathology)
- Male
- Systole
- Ventricular Outflow Obstruction
(complications, physiopathology)
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