Abstract | OBJECTIVE AND DESIGN: MATERIALS AND METHODS: Rats were fed for 8 weeks with BD, HOSO, VOO, PSVOO, POL and FO diets before injecting carrageenan. Rats were fed for 3 weeks with BD, PSVOO and FO diets before induction of adjuvant arthritis. Dietary treatment with or without indomethacin continued during 3 weeks. The data were evaluated using an analysis of variance (ANOVA) followed by the least-significant differences. RESULTS: In carrageenan oedema test, the inflammation indices of animals fed on a diet rich in olive oil (VOO) were lower compared to animals fed with oils high in oleic acid (HOSO, POL) and polyunsaturated fatty acids (FO), and markedly diminished in the group fed on PSVOO. In established adjuvant arthritis, the PSVOO diet was even more effective than FO diet in the prevention of inflammation. Both groups of animals showed an increase in weight during the latter days of the experiment compared to the BD. Indomethacin administered to every diet group, exerted a strong inhibitory effect on the inflammatory process throughout which was augmented by the PSVOO and FO diets. CONCLUSIONS: This study demonstrates that virgin olive oil with a higher content of polyphenolic compounds, similar to that of extra virgin olive oil, shows protective effects in both models of inflammation and improves the disease associated loss of weight. This supplementation also augmented the effects of drug therapy.
|
Authors | E Martínez-Domínguez, R de la Puerta, V Ruiz-Gutiérrez |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 50
Issue 2
Pg. 102-6
(Feb 2001)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 11289653
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Dietary Fats, Unsaturated
- Fish Oils
- Flavonoids
- Olive Oil
- Phenols
- Plant Oils
- Polymers
- Polyphenols
- Sunflower Oil
- Palm Oil
- Carrageenan
|
Topics |
- Animals
- Arthritis, Experimental
(therapy)
- Carrageenan
- Dietary Fats, Unsaturated
- Edema
(chemically induced, therapy)
- Fish Oils
(administration & dosage)
- Flavonoids
- Inflammation
(therapy)
- Male
- Olive Oil
- Palm Oil
- Phenols
(administration & dosage, therapeutic use)
- Plant Oils
(administration & dosage)
- Polymers
(administration & dosage, therapeutic use)
- Polyphenols
- Rats
- Rats, Wistar
- Sunflower Oil
|