Abstract | BACKGROUND/AIMS: METHODS: We investigated the mitochondrial effects and metabolic activation of buprenorphine in isolated rat liver mitochondria and microsomes, and its toxicity in isolated rat hepatocytes and treated mice. RESULTS: CONCLUSIONS:
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Authors | A Berson, D Fau, R Fornacciari, P Degove-Goddard, A Sutton, V Descatoire, D Haouzi, P Lettéron, A Moreau, G Feldmann, D Pessayre |
Journal | Journal of hepatology
(J Hepatol)
Vol. 34
Issue 2
Pg. 261-9
(Feb 2001)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 11281555
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Narcotics
- Uncoupling Agents
- Buprenorphine
- norbuprenorphine
- Adenosine Triphosphate
- Cytochrome P-450 Enzyme System
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP3A
- Oxidoreductases, N-Demethylating
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Topics |
- Adenosine Triphosphate
(biosynthesis)
- Alkylation
- Animals
- Aryl Hydrocarbon Hydroxylases
- Biotransformation
- Buprenorphine
(analogs & derivatives, pharmacokinetics, toxicity)
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
(metabolism)
- In Vitro Techniques
- Liver
(drug effects, metabolism)
- Male
- Membrane Potentials
(drug effects)
- Mice
- Mice, Inbred ICR
- Microsomes, Liver
(drug effects, metabolism)
- Mitochondria, Liver
(drug effects, metabolism)
- Narcotics
(pharmacokinetics, toxicity)
- Oxidation-Reduction
- Oxidoreductases, N-Demethylating
(metabolism)
- Permeability
- Protein Binding
- Rats
- Rats, Sprague-Dawley
- Uncoupling Agents
(pharmacology)
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