Apoptosis, bcl-2 expression, and p53 expression in gastrointestinal stromal/smooth muscle tumors.

Abstract

The authors investigated the relations between outcome and apoptosis, immunohistochemical demonstration of bcl-2 protein, and immunohistochemical staining for p53 protein in patients with gastrointestinal stromal/smooth muscle tumors (GIST). Patients whose tumors demonstrated cellular apoptosis using the terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling (TUNEL) assay had an improved survival over those whose tumors did not improve. In contrast, patients whose tumors demonstrated staining for bcl-2 protein had a decreased survival compared with those whose tumors did not demonstrate bcl-2. There was no relation between p53 immunoreactivity and survival. These results suggest that inhibition of apoptosis may be associated with malignant behavior in patients with gastrointestinal stromal/smooth muscle tumors.

• Authors: R E Cunningham, S L Abbondanzo, W S Chu, T S Emory, L H Sobin, T J O'Leary
• Journal: Applied immunohistochemistry & molecular morphology : AIMM (Appl Immunohistochem Mol Morphol) Vol. 9 Issue 1 Pg. 19-23 (Mar 2001) ISSN: 1541-2016 [Print] United States
• PMID: 11277409 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Proto-Oncogene Proteins c-bcl-2
• Tumor Suppressor Protein p53

Topics

• Apoptosis
• Gastrointestinal Neoplasms (metabolism, pathology)
• Humans
• Immunohistochemistry
• In Situ Nick-End Labeling
• Leiomyoma (metabolism, pathology)
• Leiomyosarcoma (metabolism, pathology)
• Mitotic Index
• Neoplasms, Connective Tissue (metabolism, pathology)
• Neoplasms, Muscle Tissue (metabolism, pathology)
• Proto-Oncogene Proteins c-bcl-2 (metabolism)
• Tumor Suppressor Protein p53 (metabolism)