HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency.

AbstractOBJECTIVE:
To determine effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency.
ANIMALS:
32 cats.
PROCEDURE:
Renal mass was surgically reduced, and cats were assigned to 1 of 4 eight-cat groups. Group 1 received placebo, whereas groups 2, 3, and 4 received benazepril hydrochloride orally once daily for approximately 6.5 months at the following doses: group 2, 0.25 to 0.50 mg/kg of body weight; group 3, 0.50 to 1.00 mg/kg; and group 4, 1.00 to 2.00 mg/kg. Arterial blood pressures, glomerular filtration rate (GFR), and renal plasma flow were determined before treatment and during the treatment period. Other determinants of renal hemodynamics were measured by use of micropuncture techniques. Renal biopsy specimens were examined microscopically.
RESULTS:
Compared with cats that received placebo, mean systolic arterial blood pressure was significantly less and GFR significantly greater in cats that received benazepril. Glomerular capillary pressure and the ratio of efferent to afferent arteriolar vascular resistance were also significantly less in treated cats. However, histologic differences in renal specimens were not detected.
CONCLUSIONS AND CLINICAL RELEVANCE:
Treatment with benazepril sustained single nephron GFR in remnant nephrons of cats with induced renal insufficiency. Administration of benazepril was also associated with a small but significant reduction in degree of systemic hypertension and an increase in whole kidney GFR. Benazepril may be an effective treatment to slow the rate of progression of renal failure in cats with renal disease.
AuthorsS A Brown, C A Brown, G Jacobs, J Stiles, R S Hendi, S Wilson
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 62 Issue 3 Pg. 375-83 (Mar 2001) ISSN: 0002-9645 [Print] United States
PMID11277203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiotensin-Converting Enzyme Inhibitors
  • Benzazepines
  • Creatinine
  • benazepril
Topics
  • Angiotensin-Converting Enzyme Inhibitors (pharmacology)
  • Animals
  • Benzazepines (pharmacology)
  • Blood Pressure
  • Blood Urea Nitrogen
  • Cat Diseases (drug therapy, physiopathology)
  • Cats
  • Creatinine (blood, urine)
  • Echocardiography (veterinary)
  • Female
  • Glomerular Filtration Rate (drug effects, veterinary)
  • Heart Rate (drug effects)
  • Hypertension, Renal (etiology, prevention & control)
  • Kidney Diseases (drug therapy, physiopathology, veterinary)
  • Male
  • Random Allocation
  • Renal Plasma Flow (drug effects)
  • Telemetry (veterinary)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: