Enterostatin (VPDPR) has anti-analgesic and anti-amnesic activities.

Abstract

Enterostatin (VPDPR), an anorexigenic peptide derived from the amino terminus of procolipase, significantly inhibited analgesia induced by the mu-opioid agonist morphine (5 mg/kg, s.c.) after i.c.v. administration to mice at a dose of 100 nmol. On the other hand, VPDPR (approximately 200 nmol, i.c.v.) did not attenuate analgesia induced by the kappa-opioid agonist D-Phe-D-Phe-D-Nle-D-Arg-NH2 (100 microg/mouse, i.c.v.) or delta-opioid agonist DTLET (4 nmol/mouse, i.c.v.). VPDPR (100 nmol, i.c.v.) significantly improved amnesia induced by scopolamine (0.2 mg/kg, i.p.) in mice. However, VPDPR did not enhance memory in normal mice at the same dose.

• Authors: Y Takenaka, F Nakamura, Y Jinsmaa, A W Lipkowski, M Yoshikawa
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 65 Issue 1 Pg. 236-8 (Jan 2001) ISSN: 0916-8451 [Print] England
• PMID: 11272841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Anesthesia
• Analgesics, Opioid
• Colipases
• Enzyme Precursors
• Oligopeptides
• Protein Precursors
• procolipase
• Morphine
• deltakephalin
• Scopolamine

Topics

• Adjuvants, Anesthesia (pharmacology)
• Amnesia (chemically induced, drug therapy)
• Analgesics, Opioid (antagonists & inhibitors)
• Animals
• Colipases (pharmacology, therapeutic use)
• Enzyme Precursors
• Male
• Memory (drug effects)
• Mice
• Mice, Inbred Strains
• Morphine (antagonists & inhibitors, pharmacology)
• Oligopeptides (pharmacology)
• Protein Precursors (pharmacology, therapeutic use)
• Scopolamine (pharmacology)