[Redergin treatment of hypertensive menopausal women].

Abstract

AIM:

To assess a hypotensive effect of redergin (dihydroergotoxin)--agonist of dopaminergic receptors--in monotherapy (4.5-6 mg/day) and in combination with enalapril and amlodipin (10 mg/day).

MATERIAL AND METHODS:

Redergin in monotherapy or combined therapy was given to 106 hypertensive women in pre- or postmenopause and 24 hypertensive women of reproductive age. Antihypertensive effect was assessed by changes in arterial pressure, frequency and severity of hypertensive crises, diuresis, clinical symptoms of menopausal syndrome.

RESULTS:

A significant fall in arterial pressure, intensive diuresis, less frequent or absent hypertensive crises, relief of menopausal symptoms were observed on day 10-14 of redergin monotherapy of menopausal patients with mild hypertension and in combined treatment of menopausal women with moderate and severe hypertension.

CONCLUSION:

Antihypertensive and diuretic effect of redergin confirm a pathogenetic role of deficient dopaminergic activity in development of menopausal hypertension.

• Authors: E V Iarnykh, S I Chikovani, S E Ustinova, V P Masenko
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 72 Issue 11 Pg. 47-50 ( 2000) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Opyt primeneniia redergina u bol'nykh arterial'noĭ gipertonieĭ klimaktericheskogo perioda.
• PMID: 11270957 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Receptors, Dopamine
• Vasodilator Agents
• Ergoloid Mesylates

Topics

• Adult
• Blood Pressure (drug effects)
• Diuresis (drug effects)
• Ergoloid Mesylates (therapeutic use)
• Female
• Humans
• Hypertension (drug therapy, metabolism, physiopathology)
• Menopause
• Middle Aged
• Receptors, Dopamine (drug effects)
• Severity of Illness Index
• Treatment Outcome
• Vasodilator Agents (therapeutic use)