Abstract | BACKGROUND: METHODS: RESULTS: Out of 97 tumors, 38 (39.2%) were positively stained with AMFR. The AMFR expression was significantly associated with histologic type of tumor, mainly in adenocarcinoma. Overall survival of patients with AMFR-positive tumors was significantly worse than that of AMFR-negative tumors (p = 0.0050). The AMFR expression appears to be associated with VEGF expression. Patients who were AMFR positive and had high VEGF expression had a worse prognosis compared with the AMFR-negative and low VEGF-expression group (p < 0.0001). Multivariate analysis revealed an independent prognostic impact of AMFR on survival (p = 0.0039). CONCLUSIONS: These results indicate that evaluation of AMFR expression may provide useful guidance in follow-up of patients with NSCLC.
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Authors | M Kara, Y Ohta, Y Tanaka, M Oda, Y Watanabe |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 71
Issue 3
Pg. 944-8
(Mar 2001)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 11269478
(Publication Type: Journal Article)
|
Chemical References |
- Receptors, Cytokine
- AMFR protein, human
- Receptors, Autocrine Motility Factor
- Ubiquitin-Protein Ligases
|
Topics |
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(metabolism, mortality, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lung Neoplasms
(metabolism, mortality, pathology)
- Male
- Middle Aged
- Neoplasm Staging
- Prognosis
- Receptors, Autocrine Motility Factor
- Receptors, Cytokine
(biosynthesis)
- Survival Rate
- Ubiquitin-Protein Ligases
|