Prognostic value of circulating sialyl Tn antigen in colorectal cancer patients.

Abstract

To examine the prognostic value of assessing the concentration of circulating sialyl Tn antigen (STN) after surgery, we determined serum STN levels in peripheral venous blood (designated "p-") in 308 colorectal cancer patients and what we have termed the "d-p gradient" (obtained by subtracting the serum concentration in peripheral venous blood from that in the tumor's drainage venous blood) in 144 patients. The prognostic value of STN and carcinoembryonic antigen (CEA) was compared. Patients were divided into low or high p-antigen groups and low, intermediate, or high d-p gradient groups. Univariate and multivariate analyses revealed that high STN d-p gradient, high p-CEA, or high CEA d-p gradient were each independent variables for poor patient outcome after surgery, separate from stage. In conclusion, a high STN d-p gradient was a predictor of poor outcome after resection for colorectal cancer, while p-STN was not independent of stage.

• Authors: T Nakagoe, T Sawai, T Tsuji, M Jibiki, A Nanashima, H Yamaguchi, N Kurosaki, T Yasutake, H Ayabe, Y Tagawa
• Journal: Anticancer research (Anticancer Res) 2000 Sep-Oct Vol. 20 Issue 5C Pg. 3863-9 ISSN: 0250-7005 [Print] Greece
• PMID: 11268468 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• Carcinoembryonic Antigen
• sialosyl-Tn antigen

Topics

• Adult
• Aged
• Aged, 80 and over
• Analysis of Variance
• Antigens, Tumor-Associated, Carbohydrate (blood)
• Biomarkers, Tumor (blood)
• Carcinoembryonic Antigen (blood)
• Colorectal Neoplasms (blood, mortality, pathology, surgery)
• Female
• Humans
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Staging
• Predictive Value of Tests
• Prognosis
• Survival Analysis