Abstract |
Androstenetriol ( AET) and Androstenediol (AED) upregulate host immunity, leading to increased resistance against infections. AET augments IL-2, IL-3, IFN gamma levels, and counteracts hydrocortisone immune suppression. AET and AED at a dose of 0.75 mg/- and 8.0 mg/25-g mouse, protected 60 and 70%, respectively, of C57/BL/6J mice irradiated with a lethal dose. These hormones also protected mice irradiated with 6 Gy and infected with a coxsackievirus B4 LD50. AET significantly increased spleen lymphocyte numbers at 7, 14, and 21 days after a 6-Gy exposure. Fluorescent activated cell-sorter analysis of irradiated mice, spleen, and bone marrow showed that AET significantly augmented the myeloid precursor markers, CD11b/Mac-1, and B220 (pan B), as well as the absolute numbers of CD4+/CD8+ cells over the 21 days of testing. Overall, the data are consistent with AET/AED inducing a more rapid recovery of all hematopoietic precursors from the small number of surviving stem cells.
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Authors | R M Loria, D H Conrad, T Huff, H Carter, D Ben-Nathan |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 917
Pg. 860-7
( 2000)
ISSN: 0077-8923 [Print] United States |
PMID | 11268417
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anabolic Agents
- Androstenediol
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Topics |
- Anabolic Agents
(pharmacology, therapeutic use)
- Androstenediol
(immunology, pharmacology, therapeutic use)
- Animals
- Immunity
(drug effects)
- Male
- Mice
- Mice, Inbred C57BL
- Neuroimmunomodulation
- Radiation Injuries
(immunology, prevention & control)
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