Anticonvulsant properties of N-salicyloyltryptamine in mice.

Abstract

A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of animals that exhibited PTZ-induced seizures and eliminated the extensor reflex of maximal electric-induced seizures test in 50% of the experimental animals. In addition, it showed protection in the PTZ test by diminishing the death rate.

• Authors: F A Oliveira, R N de Almeida, M F Sousa, J M Barbosa-Filho, S A Diniz, I A de Medeiros
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 68 Issue 2 Pg. 199-202 (Feb 2001) ISSN: 0091-3057 [Print] United States
• PMID: 11267623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Convulsants
• Tryptamines
• tryptamine
• Pentylenetetrazole

Topics

• Animals
• Anticonvulsants (chemistry, therapeutic use)
• Convulsants
• Drug Evaluation, Preclinical
• Electroshock
• Male
• Mice
• Pentylenetetrazole
• Seizures (chemically induced, drug therapy)
• Tryptamines (chemistry, therapeutic use)