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Primary biliary cirrhosis: MR imaging findings and description of MR imaging periportal halo sign.

AbstractOBJECTIVE:
This study reviews the prevalence of MR imaging abnormalities seen in 21 consecutive patients with primary biliary cirrhosis before transplantation and describes a new MR imaging sign in these patients: the MR imaging periportal halo sign.
CONCLUSION:
Abdominal adenopathy was present in 62% of the patient population, and none of the patients with adenopathy had a known malignancy. Findings associated with end-stage cirrhosis and portal hypertension were seen and included ascites (62%), splenomegaly (71%), portosystemic collaterals (57%), portal vein thrombosis (5%), and hepatocellular carcinoma (5%). The MR imaging periportal halo sign was seen in 43% of patients with primary biliary cirrhosis, but none of the patients in a sex- and age-matched cohort of 21 patients with cirrhosis not caused by primary biliary cirrhosis had the finding. Statistical analysis of these results produced a t score of 3.97 and a p value of less than 0.001, suggesting that this new MR imaging sign is highly specific for the diagnosis of primary biliary cirrhosis.
AuthorsJ S Wenzel, A Donohoe, K L Ford 3rd, K Glastad, D Watkins, E Molmenti
JournalAJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 176 Issue 4 Pg. 885-9 (Apr 2001) ISSN: 0361-803X [Print] United States
PMID11264071 (Publication Type: Journal Article)
Topics
  • Carcinoma, Hepatocellular (pathology)
  • Humans
  • Hypertension, Portal (diagnosis)
  • Liver Cirrhosis, Biliary (diagnosis, etiology, surgery)
  • Liver Neoplasms (pathology)
  • Liver Regeneration (physiology)
  • Liver Transplantation
  • Lymph Nodes (pathology)
  • Magnetic Resonance Imaging
  • Portal Vein (pathology)
  • Retrospective Studies
  • Splenomegaly (diagnosis)
  • Thrombosis (diagnosis)

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