[The effect of tilidine on left-ventricular function of the human heart (author's transl)].

Abstract

The effect of tilidine (Valoron, 1.5 mg/kg) on left-ventricular function was measured in ten patients undergoing diagnostic cardiac catheterization. In the course of thirty minutes after administration there was a small fall in systemic arterial pressure, decrease in cardiac output, cardiac index and stroke volume, as well as a change in the isovolumetric inotropic state. Haemodynamic and inotropic changes were small in amount, varying between 3.4 and 14.5% of basal values. This study indicates that tilidine, while having a powerful analgesic effect, has only a mild contractility-inhibiting action. Tilidine is thus a useful alternative as an analgesic in cardiac pain.

• Authors: B E Strauer
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 100 Issue 14 Pg. 760-3 (Apr 04 1975) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Die Wirkung von Tilidin auf die linksventrikuläre Dynamik des menschlichen Herzens
• PMID: 1126283 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclohexanecarboxylic Acids
• Tilidine

Topics

• Adult
• Blood Pressure (drug effects)
• Cardiac Catheterization
• Cardiac Output (drug effects)
• Cyclohexanecarboxylic Acids (pharmacology)
• Heart (drug effects)
• Heart Ventricles
• Humans
• Middle Aged
• Muscle Contraction (drug effects)
• Tilidine (pharmacology)